Acetic Acid → HCID 20519163, 화합물

HRID 2198516노트

반응식

HRID 2198516 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([NH:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([CH2:30][CH3:31])([CH3:29])[CH3:28])=[CH:23][C:22]=2[C:32]([CH2:35][CH3:36])([CH3:34])[CH3:33])=[O:14])[CH:3]=1.[CH3:37][O:38][C:39](=[O:53])[C:40]1[CH:45]=[CH:44][C:43]([S:46](Cl)(=[O:48])=[O:47])=[CH:42][C:41]=1[N+:50]([O-:52])=[O:51].N1C=CC=CC=1.C(O)(=O)C>C(Cl)Cl>[C:32]([C:22]1[CH:23]=[C:24]([C:27]([CH2:30][CH3:31])([CH3:28])[CH3:29])[CH:25]=[CH:26][C:21]=1[O:20][CH2:19][CH2:18][CH2:17][CH2:16][NH:15][C:13]([C:4]1[CH:3]=[C:2]([NH:1][S:46]([C:43]2[CH:44]=[CH:45][C:40]([C:39]([O:38][CH3:37])=[O:53])=[C:41]([N+:50]([O-:52])=[O:51])[CH:42]=2)(=[O:47])=[O:48])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]=1[OH:12])=[O:14])([CH2:35][CH3:36])([CH3:34])[CH3:33]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 1049PyridineHCID 30848622-Naphthalenecarboxamide, 4-amino-N-[4-[2,4-bis(1,1-dimethylpropyl)phenoxy]butyl]-1-hydroxy-HCID 20519165Methyl 4-(chlorosulfonyl)-2-nitrobenzoate

생성물 1

HCID 20519163HCID 20519163, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Amino-N-[4-(2,4-di-t-pentylphenoxy)butyl]-1-hydroxy-2-naphthamide (11.7 g, 23.8 mmoles) was dissolved in methylene chloride (300 ml) under nitrogen and reacted with intermediate (B) (6.7 g, 25.2 mmoles) in the presence of pyridine (2.0 g). After 5 hours of stirring at room temperature, acetic acid (2 ml) was added and the mixture was evaporated to dryness. Trituration of the residue gave a solid which was collected by filtration and recrystallized from ethanol; yield, 8.0 g (46.8 percent).

후처리

  1. customthe mixture was evaporated to dryness
  2. customTrituration of the residue gave a solid which
  3. filtrationwas collected by filtration
  4. customrecrystallized from ethanol
  5. customyield

출처 및 근거

ORD 기록
ord-5b5fb246c7394beab2c3c1a26804e0ca
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04358404

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