Ethanol → 4-(4-(Methylsulfonyl)piperazin-1-yl)phenol

HRID 2198526

반응식

HRID 2198526 반응식
Br.Br.[N:3]1([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(O)C.C(=O)([O-])O.[Na+].[CH3:24][S:25](Cl)(=[O:27])=[O:26]>O>[OH:15][C:12]1[CH:11]=[CH:10][C:9]([N:3]2[CH2:4][CH2:5][N:6]([S:25]([CH3:24])(=[O:27])=[O:26])[CH2:7][CH2:8]2)=[CH:14][CH:13]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 31297Methanesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 2723591p-(1-Piperazinyl)phenol dihydrobromide

생성물 1

HCID 6400494-(4-(Methylsulfonyl)piperazin-1-yl)phenol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred mixture of 12.9 parts of 4-(1-piperazinyl)-phenol dihydrobromide, 40 parts of ethanol and 50 parts of water are added 12.6 parts of sodium hydrogen carbonate. Then there are added dropwise 6.4 parts of methanesulfonyl chloride at 0° C. Upon completion, stirring is continued overnight. The precipitated product is filtered off and taken up in water. The whole is alkalized with a sodium hydroxide solution and stirred for 30 minutes at room temperature. The mixture is filtered over hyflo and the filtrate is acidified with acetic acid. The precipitated product is filtered off and dried, yielding 2.8 parts of 1-(4-hydroxyphenyl)-4-(methylsulfonyl)-piperazine; mp. 204.9° C.

후처리

  1. filtrationThe precipitated product is filtered off
  2. stirringstirred for 30 minutes at room temperature
  3. filtrationThe mixture is filtered over hyflo
  4. filtrationThe precipitated product is filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-ec80264623f1485e9509d3d39ae6ff60
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04358449

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