Aniline → N''-Butyl-N,N,N',N'-tetramethyl-guanidine

HRID 2198576

반응식

[NH2:1][C:2]1C=C[CH:5]=[CH:4][CH:3]=1.C(N)CCC.[CH2:13]([N:15]([CH2:18]C)[CH2:16]C)C.C1C=[C:24]([NH:26][C:27]2NC3N=CNC=3C(=O)N=2)C=C(C(F)(F)F)C=1>>[CH2:2]([N:1]=[C:13]([N:26]([CH3:27])[CH3:24])[N:15]([CH3:18])[CH3:16])[CH2:3][CH2:4][CH3:5]

참가 물질

반응물 4

HCID 6115Aniline

HCID 8007Butylamine

HCID 8471Triethylamine

HCID 178517994HCID 178517994, 화합물

생성물 1

HCID 525255N''-Butyl-N,N,N',N'-tetramethyl-guanidine수율 84%

실험 절차

The procedure of Example 4 was repeated, except that the solution of aniline in TMPG was replaced with a solution of n-butylamine (36.6 g, 0.5 mole) in triethylamine (51 g, 0.5 mole). Workup and distillation, as indicated, yielded 72.0 g (0.42 mole) of N"-butyl-N,N,N',N'-tetramethyl guanidine, bp. 31°-32° C. at 0.03 mm, nD22.3 1.4600, which corresponded to 84% yield of the theory.

후처리

distillationWorkup and distillation

출처 및 근거

ORD 기록: ord-701a3db9898b42f4a7c46a6c4ff8d200
출처 데이터셋: uspto-grants-1982_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04358613

연결된 노트

불러오는 중…