Methyl 2-fluoro-5-methoxy-4-nitrobenzoate → Methyl 4-amino-2-fluoro-5-methoxybenzoate
반응식
[F:1][C:2]1[CH:11]=[C:10]([N+:12]([O-])=O)[C:9]([O:15][CH3:16])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]>CO.[Pd]>[NH2:12][C:10]1[C:9]([O:15][CH3:16])=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([F:1])[CH:11]=1참가 물질
4
실험 절차
Methyl 2-fluoro-5-methoxy-4-nitrobenzoate (549 mg; 1.13 mmol; 1 eq.) was dissolved in MeOH (50 mL). The resulting solution was injected on a flow hydrogenation reactor (H-Cube), adapted with Pd/C cartridge (44 mm), a flow of 1 mL/min, a temperature of 60° C. and the full H2 option enabled. Solvents were evaporated, affording the title product as an off-white solid (220 mg; 97%). LC/MS (Method B): 200.0 (M+H)+. HPLC (Method A) Rt 3 min (Purity: 91.9%).
후처리
- customThe resulting solution was injected on a flow hydrogenation reactor
- customa temperature of 60° C.
- customSolvents were evaporated
출처 및 근거
- ORD 기록
- ord-dc4443a2126b496988c907898b32512d
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08202865B2
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