Dimethylformamide → N-[3-(4-oxo-piperidino)-propyl]-benzimidazolone
반응식
Cl[CH2:2][CH2:3][CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6]1=[O:14].[C:15](=O)(O)[O-].[Na+].[O:20]1[CH2:24][CH2:23][CH2:22]C1.C[N:26]([CH3:29])C=O>>[O:20]=[C:24]1[CH2:15][CH2:29][N:26]([CH2:2][CH2:3][CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[NH:7][C:6]2=[O:14])[CH2:22][CH2:23]1참가 물질
5
실험 절차
A mixture of 6.3 gm of N-(3-chloropropyl)-benzimidazolone, 4.6 gm of 4-piperidine hydrochloride monohydrate, 5.0 gm of sodium bicarbonate, 50 ml of tetrahydrofuran, and 50 ml of dimethylformamide, was heated to reflux, for 36 hours. The product was worked up as usual, yielding 3.2 gm (39% of theory) of N-[3-(4-oxo-piperidino)-propyl]-benzimidazolone, m.p. 134°-136° C.