Ammonia → HCID 20517506, 화합물

HRID 2198888노트

반응식

HRID 2198888 반응식
[CH2:1]([C:3]([CH2:13][NH:14][CH2:15][CH:16]([OH:18])[CH3:17])([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[CH:6]=1)O)[CH3:2].S(=O)(=O)(O)O.O.N>CCOCC>[CH2:1]([C:3]1([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[CH:6]=2)[O:18][CH:16]([CH3:17])[CH2:15][NH:14][CH2:13]1)[CH3:2]

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 962WaterHCID 1118Sulfuric AcidHCID 54355367HCID 54355367, 화합물

생성물 1

HCID 20517506HCID 20517506, 화합물수율 21.9%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

METHOD A The product from Example 15 (1.77 g, 0.007 mole) was treated dropwise at 0° C. with concentrated sulphuric acid (2.3 ml). The resulting green gum was allowed to stand overnight at room temperature and was then treated with 25 ml of crushed ice and after thorough mixing, 50 ml of water. The solution was neutralised with excess ammonia and the solution shaken with ether (2×50 ml). The ether layers were washed, and dried (MgSO4) and evaporated to give 360 mg of the title compound as a 50:50 mixture of diastereoisomers.

후처리

  1. washThe ether layers were washed
  2. dry with materialdried (MgSO4)
  3. customevaporated

출처 및 근거

ORD 기록
ord-1d1b7dc4e82d406195fa805c8eb7664d
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04360519

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