Hydrazine → 2-Hydrazino-9-(2-hydroxyethoxymethyl)adenine

반응식

Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][O:12][CH2:13][CH2:14][OH:15])=[C:4]([NH2:16])[N:3]=1.[NH2:17][NH2:18]>>[NH:17]([C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][O:12][CH2:13][CH2:14][OH:15])=[C:4]([NH2:16])[N:3]=1)[NH2:18]

참가 물질

반응물 2

HCID 9321Hydrazine

HCID 128995862-Chloro-9-(2-hydroxyethoxymethyl)adenine

생성물 1

HCID 867364332-Hydrazino-9-(2-hydroxyethoxymethyl)adenine

실험 절차

2-Chloro-9-(2-hydroxyethoxymethyl)adenine (0.83 g) was added with stirring to 95% hydrazine (11 ml) and the resulting solution stirred 1 hour under nitrogen. Excess hydrazine was removed by distillation in a rotary evaporator at a bath temperature of 30° C. followed by co-evaporation twice with ethyl acetate. The residue was thoroughly triturated with methanol to give a quantitative yield (0.8 g) of white to cream colored-2-hydrazino-9-(2-hydroxyethoxymethyl)adenine, m.p. 220°-222° C.

후처리

customExcess hydrazine was removed by distillation in a rotary evaporator at a bath temperature of 30° C.
customThe residue was thoroughly triturated with methanol

출처 및 근거

ORD 기록: ord-122d8b36c9894cca95a65c1ca9d05580
출처 데이터셋: uspto-grants-1982_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04360522

반응 노트

불러오는 중…