Formic Acid → 2-[(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]ethyl formate

HRID 2198925노트

반응식

HRID 2198925 반응식
[OH:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[O:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2.[CH:17](O)=[O:18]>CCOCC>[CH:17]([O:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[O:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2)=[O:18]

참가 물질

4

반응물 2

HCID 284Formic AcidHCID 135398513Acyclovir

생성물 1

HCID 1361209032-[(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]ethyl formate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 9(2-hydroxyethoxymethyl)guanine (4.73 g) in 97% formic acid (24 ml) was stirred at room temperature overnight. The amber solution was diluted with about 200 ml of dry ether and chilled. The resulting white precipitate was filtered, dried and recrystallized from dry dimethylformamide to give 9-(2-formyloxyethoxymethyl)guanine (3.6 g, m.p. 225°-227° C.).

후처리

  1. temperaturechilled
  2. filtrationThe resulting white precipitate was filtered
  3. customdried
  4. customrecrystallized from dry dimethylformamide

출처 및 근거

ORD 기록
ord-f9f7b89b21394acba281ebbbc579a0bc
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04360522

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