Ethanol → Benzoic acid, 4-fluoro-, ethyl ester

HRID 2199

반응식

HRID 2199 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH2:11]([OH:13])[CH3:12]>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:13][CH2:11][CH3:12])=[O:7])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 702EthanolHCID 678794-Fluorobenzoyl chloride

생성물 1

HCID 67976Benzoic acid, 4-fluoro-, ethyl ester

실험 절차

A mixture containing 35 g of 4-fluorobenzoyl chloride in 50 ml of 100% ethanol is refluxed for 15 minutes. 35 g of the ethyl 4-fluorobenzoate obtained are mixed with 22 g of imidazole and 61 g of potassium carbonate in 35 ml of DMSO. The mixture is heated for 18 hours at 120°-130° C. and 500 ml of iced water are then added. A precipitate forms and the expected product crystallizes from iso ether.

후처리

  1. temperatureis refluxed for 15 minutes

출처 및 근거

ORD 기록
ord-43d95d9c07ef43d581eb72b8af369b67
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728723

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