Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → N-[4-(1-Piperazinyl)butyl]-3,3-dimethylglutarimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4,4-Dimethylpiperidine-2,6-dione | HCID 14292 | — |
| 반응물 | 1-(4-Bromobutyl)-4,4-dimethylpiperidine-2,6-dione | HCID 13660335 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-[4-(1-Piperazinyl)butyl]-3,3-dimethylglutarimide | HCID 20516935 | 85% |
반응 단계
A mixture of N-(4-bromobutyl)-3,3-dimethylglutarimide (20.0 g; 0.07 mole [prepared from 3,3-dimethylglutarimide using the method of Example 2]); piperazine (31.0 g; 0.36 mole); K2CO3 (29.8 g; 0.22 mole); and KI (0.1 g) was refluxed in 250 mL acetonitrile for 18 hr. The mixture was filtered, concentrated and the unreacted piperazine removed by vacuum sublimation. The residual material was distilled to yield 17.2 g (85%) product, b.p. 170°-178° C. at 0.01 mm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04361565 |
| 출처 데이터셋 | uspto-grants-1982_11 |
| ORD ID | ord-613b4dba2a814f92b4367ed0edb4cfd4 |
| 출처 메모 | uspto-grants-1982_11 |