5-(Prop-1-en-2-yl)pyridin-2-amine → 5-(Propan-2-yl)pyridin-2-amine

HRID 2199595노트

반응식

HRID 2199595 반응식
[CH2:1]=[C:2]([C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=1)[CH3:3]>CO.[Pd]>[CH3:1][CH:2]([C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=1)[CH3:3]

참가 물질

4

반응물 1

HCID 552857655-(Prop-1-en-2-yl)pyridin-2-amine

생성물 1

HCID 179858055-(Propan-2-yl)pyridin-2-amine수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

In a Parr flask, a mixture of 1.1 g (8.2 mmol) of 5-(prop-1-en-2-yl)pyridin-2-amine in 40 mL of MeOH and 0.11 g of 10% Pd/C is hydrogenated at 7 bar for 24 hours. The reaction mixture is then filtered through Whatman GF/F paper and concentrated under reduced pressure. 1.07 g of 5-(propan-2-yl)pyridin-2-amine are thus obtained in the form of a yellow oil, which is used without further purification in the following step.

후처리

  1. filtrationThe reaction mixture is then filtered through Whatman GF/F paper
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a8709211cc624db3a7514ede4aa9af86
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359329B2

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