1-Methanesulfonyl-3-nitro-5-trifluoromethylbenzene → 3-Methanesulfonyl-5-(trifluoromethyl)aniline

HRID 2200124노트

반응식

HRID 2200124 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([N+:15]([O-])=O)[CH:6]=1)(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=1)[NH2:15])(=[O:4])=[O:3]

참가 물질

4

반응물 1

HCID 684231001-Methanesulfonyl-3-nitro-5-trifluoromethylbenzene

생성물 1

HCID 592861463-Methanesulfonyl-5-(trifluoromethyl)aniline수율 73.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Stir the mixture of 1-(methylsulfonyl)-3-nitro-5-(trifluoromethyl)benzene (2 g, 7.43 mmol), Pd/C (10%, 500 mg) in methanol (100 mL) under hydrogen atmosphere at room temperature for 15 hrs. Filter off the solid and concentrate the filtrate under reduced pressure. Purify the residue with flash chromatography (silica gel, EtOAc:PE=1:5) to afford the desired product (1.3 g, 73%). MS: (M+23): 262.0.

후처리

  1. filtrationFilter off the solid
  2. concentrationconcentrate the filtrate under reduced pressure
  3. customPurify the residue with flash chromatography (silica gel, EtOAc:PE=1:5)

출처 및 근거

ORD 기록
ord-ef311f5d17df41ff838e414a251bdca7
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359338B2

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