Formaldehyde → (3-Bromo-5-(trifluoromethyl)phenyl)(1-methylpiperidin-4-yl)methanone
반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:12]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[O:13])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:20]=O>C(O)=O>[Br:1][C:2]1[CH:3]=[C:4]([C:12]([CH:14]2[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]2)=[O:13])[CH:5]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:7]=1참가 물질
4
실험 절차
Stir the mixture of (3-bromo-5-(trifluoromethyl)phenyl)(piperidin-4-yl)methanone (400 mg, 0.96 mmol), formic acid (1 mL) and formaldehyde (1 mL) at 100° C. overnight. Upon the reaction completion, concentrate under reduced pressure to provide the crude product (250 mg, 77%) which is used in next step without further purification.
후처리
- concentrationUpon the reaction completion, concentrate under reduced pressure
출처 및 근거
- ORD 기록
- ord-5cae838b1bee4480b317dd5d8954ac40
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09359338B2
반응 노트
불러오는 중…