2-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide → N-(3-amino-5-(trifluoromethyl)phenyl)-2-methoxyacetamide

HRID 2200140노트

반응식

HRID 2200140 반응식
[CH3:1][O:2][CH2:3][C:4]([NH:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([N+:17]([O-])=O)[CH:8]=1)=[O:5]>CO.[Pd]>[NH2:17][C:9]1[CH:8]=[C:7]([NH:6][C:4](=[O:5])[CH2:3][O:2][CH3:1])[CH:12]=[C:11]([C:13]([F:15])([F:16])[F:14])[CH:10]=1

참가 물질

4

반응물 1

HCID 900201822-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide

생성물 1

HCID 90020420N-(3-amino-5-(trifluoromethyl)phenyl)-2-methoxyacetamide수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Add Pd/C (10%, 30 mg) to the solution of 2-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide (100 mg, 0.36 mmol) in methanol (6 mL), stir the mixture under hydrogen atmosphere at room temperature for 16 hrs. Filter off the solid, concentrate the filtrate under reduced pressure to yield the crude product (89 mg, 100%) which is used without further purification.

후처리

  1. filtrationFilter off the solid
  2. concentrationconcentrate the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-b07614988f5e48d597e7a8a99a8c4906
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359338B2

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