Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N'-Hydroxycyclopropanecarboximidamide → {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N'-Hydroxycyclopropanecarboximidamide | HCID 2794666 | — |
| 반응물 | 1-(Thiomorpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid | HCID 58116561 | — |
| 생성물 | {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone | HCID 59606594 | — |
반응 단계
According to General Method 6A, 600 mg (1.491 mmol) of the compound from Example 16A and 164 mg (1.640 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted Yield: 352 mg (47% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202862B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-76e064a345914f269968413136f3f477 |
| 출처 메모 | uspto-grants-2012_06 |