HCID 89924447, 화합물 → 1226160-70-8

HRID 2200353노트

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HRID 2200353 반응식
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[CH2:10][C:9]1([CH3:22])[CH3:21])C1C=CC=CC=1>CO.C(OCC)(=O)C.[Pd]>[F:20][C:17]1[CH:16]=[CH:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][C:9]([CH3:22])([CH3:21])[CH2:10]2)=[CH:19][CH:18]=1

참가 물질

5

반응물 1

HCID 89924447HCID 89924447, 화합물

생성물 1

HCID 572767191226160-70-8

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

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온도
50 °C

실험 절차

To a stirred solution of 1-benzyl-4-(4-fluorophenyl)-2,2-dimethylpiperazine (4.5 g, 15.08 mmol) in methanol and ethyl acetate (5:1, 60 ml) at 25° C. was added 10% palladium on charcoal (1.605 g). The reaction mixture was stirred at 50° C. for 5 h. The progress of reaction was monitored by TLC. The reaction mixture was cooled to room temperature, filtered through a celite bed, washed with ethyl acetate (2×50 ml). The combined filtrate was concentrated under reduced pressure to obtain the title compound which was used in the next step without further purification.

후처리

  1. customThe progress of reaction
  2. temperatureThe reaction mixture was cooled to room temperature
  3. filtrationfiltered through a celite bed
  4. washwashed with ethyl acetate (2×50 ml)
  5. concentrationThe combined filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-cddfff64cb2a4d51a3df076ec01decaa
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359367B2

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