N'-Hydroxycyclopropanecarboximidamide → {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(1,1-difluoroethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone

HRID 220044노트

반응식

HRID 220044 반응식
[F:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][N:15]([C:17]([N:19]3[CH2:24][CH2:23][S:22][CH2:21][CH2:20]3)=[O:18])[CH2:14][CH:13]([C:25](O)=[O:26])[CH2:12]2)=[CH:7][CH:6]=1)([F:4])[CH3:3].O[N:29]=[C:30]([CH:32]1[CH2:34][CH2:33]1)[NH2:31]>>[CH:32]1([C:30]2[N:31]=[C:25]([CH:13]3[CH2:12][CH:11]([C:8]4[CH:7]=[CH:6][C:5]([C:2]([F:4])([F:1])[CH3:3])=[CH:10][CH:9]=4)[CH2:16][N:15]([C:17]([N:19]4[CH2:20][CH2:21][S:22][CH2:23][CH2:24]4)=[O:18])[CH2:14]3)[O:26][N:29]=2)[CH2:34][CH2:33]1

참가 물질

3

반응물 2

HCID 2794666N'-HydroxycyclopropanecarboximidamideHCID 581165495-[4-(1,1-Difluoroethyl)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid

생성물 1

HCID 59606568{3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(1,1-difluoroethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone

실험 절차

According to General Method 6A, 150 mg (0.376 mmol) of the compound from Example 53A and 41.5 mg (0.414 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted Yield: 77.9 mg (44% of theory)

후처리

  1. customwere reacted Yield: 77.9 mg (44% of theory)

출처 및 근거

ORD 기록
ord-911ab3139d7d46edb20f9624234d63dc
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202862B2

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