Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-3-phenylpropanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (2R)-2-amino-3-phenylpropanamide | HCID 7000171 | — |
| 반응물 | 3,5-Dichloropyrazine-2-carbonitrile | HCID 52987744 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-3-phenylpropanamide | HCID 86685588 | 85.9% |
반응 단계
A solution of 3,5-dichloropyrazine-2-carbonitrile (86 mg, 0.494 mmol), D-phenylalaninamide (81 mg, 0.494 mmol) and DIEA (0.130 mL, 0.747 mmol) in DMF (2 mL) was stirred at room temperature for 20 h. Water and EtOAc were added. Organic phase was separated, washed with 1N HCl, then with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-3-phenylpropanamide (128 mg) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09359308B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-2957b1622d0d4f708d953c960f099df7 |
| 출처 메모 | uspto-grants-2016_06 |