Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 9-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Bromo-2'-fluoroacetophenone | HCID 2737449 | — |
| 반응물 | HCID 15284093 | HCID 15284093 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 9-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one | HCID 9928570 | — |
반응 단계
A solution of 4-Amino-6-carboethoxy-5,6,7,8-tetrahydro-2(1H)-quinazolinone (262 mg) and 2'-fluoro-bromoacetophenone (217 mg) in dry DMF (10 mL) was refluxed under nitrogen for 1.5 h. The solution was cooled and 40 mL water is added. The precipitate was collected and washed successively with 10 mL of methanol and 20 mL hot ethyl acetate to yield 9-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one (Compound 1), m.p. 257°-277° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05426186 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-98d3f12fc15c4460b9226e5866bf41e6 |
| 출처 메모 | uspto-grants-1995_06 |