Dichloromethane → HCID 59173317, 화합물

HRID 220097노트

반응식

HRID 220097 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]C(=O)OC(C)(C)C)=[CH:4][C:3]=1[NH:16][C:17]1[N:21]([C:22]2[CH:27]=[C:26]([NH:28][CH3:29])[N:25]=[CH:24][N:23]=2)[N:20]=[C:19]([CH3:30])[CH:18]=1.C(Cl)Cl>C(O)(C(F)(F)F)=O>[CH3:1][C:2]1[C:3]([NH:16][C:17]2[N:21]([C:22]3[CH:27]=[C:26]([NH:28][CH3:29])[N:25]=[CH:24][N:23]=3)[N:20]=[C:19]([CH3:30])[CH:18]=2)=[CH:4][C:5]([NH2:8])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 59173418HCID 59173418, 화합물

생성물 1

HCID 59173317HCID 59173317, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

Tert-butyl 4-methyl-3-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)phenylcarbamate 38 (2.0 g) is dissolved in a mixed solvent of TFA:DCM/1:1 (20 mL). The mixture is stirred at room temperature for 4 hours, then concentrated in vacuo. The residue is dissolved in EtOAc and washed with aqueous NaHCO3. The organic layer is separated, dried with MgSO4, then concentrated in vacuo to provide 6-methyl-N1-(3-methyl-1-(6-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-yl)benzene-1,3-diamine 39.

후처리

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue is dissolved in EtOAc
  3. washwashed with aqueous NaHCO3
  4. customThe organic layer is separated
  5. dry with materialdried with MgSO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c48fe1d8ab9a441eb8b304ffacea858a
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202876B2

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