Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (R)-3-(benzyloxy)-2-(3-bromo-4-cyanophenylamino)propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Bromo-4-fluorobenzonitrile | HCID 118939 | — |
| 반응물 | O-benzyl-D-serinamide | HCID 58987402 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (R)-3-(benzyloxy)-2-(3-bromo-4-cyanophenylamino)propanamide | HCID 67509048 | 17.6% |
반응 단계
A solution of 2-bromo-4-fluorobenzonitrile (200 mg, 1.00 mmol), O-benzyl-D-serinamide (290 mg, 1.49 mmol) and DIEA (0.466 mL, 2.68 mmol) in DMSO (3 mL) was stirred at 100 C for 18 h. Water and EtOAc were added. The organic phase was separated, washed with 1N HCl, dried over Na2SO4, concentrated in vacuo. The residue was purified by a silica gel column, eluted with 0-60% EtOAc in hexane to give (R)-3-(benzyloxy)-2-(3-bromo-4-cyanophenylamino)propanamide (66 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09359375B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-7b1a324529b0441bba81e652b653dea6 |
| 출처 메모 | uspto-grants-2016_06 |