Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (R)-2-(4-cyano-3,5-difluorophenylamino)-4-methylpentanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2,4,6-Trifluorobenzonitrile | HCID 737177 | — |
| 반응물 | (R)-2-Amino-4-methylpentanamide hydrochloride | HCID 56776963 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (R)-2-(4-cyano-3,5-difluorophenylamino)-4-methylpentanamide | HCID 67509019 | 26.1% |
반응 단계
To a solution of 2,4,6-trifluorobenzonitrile (208 mg, 1.32 mmol) in DMSO (2 mL), a solution of D-leucine amide hydrochloride (220 mg, 1.32 mmol) and DIEA (0.688 mL, 3.96 mmol) in DMSO (5 mL) was added. After being stirred at room temperature for 18 h, water and EtOAc were added. The organic phase was separated, washed with water, dried over Na2SO4, concentrated in vacuo. The residue was purified by a silica gel column, eluted with 20-80% EtOAc in hexane to give (R)-2-(4-cyano-3,5-difluorophenylamino)-4-methylpentanamide (92 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09359375B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-a5e14c12274847e1ab85fbded44b6354 |
| 출처 메모 | uspto-grants-2016_06 |