Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl (1R)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethylcarbamate → D-tryptophanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl (1R)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethylcarbamate | HCID 57107549 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | D-tryptophanamide | HCID 688582 | — |
반응 단계
A solution of (R)-tert-butyl 1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamate (0.963 g, 3.18 mmol) in 4N HCl in dioxane (8 mL) was stirred at room temperature for 1 h. It was then concentrated in vacuo. The residue was partitioned between nBuOH and aq. 5% NaHCO3. The nBuOH phase was separated, washed with water, concentrated in vacuo to give (R)-2-amino-3-(1H-indol-3-yl)propanamide as free base (0.324 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09359375B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-d5cc52ab9ea44a97af10290ad8d4ef7a |
| 출처 메모 | uspto-grants-2016_06 |