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(2-Bromoethoxy)-tert-butyldimethylsilane → 2-(4-Bromo-phenyl)-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid ethyl ester

HRID 220166
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반응식

HRID 220166 반응식
Br[CH2:2][CH2:3][O:4][Si:5]([C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:7])[CH3:6].[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][CH:18]=1)[CH3:13].CC(C)([O-])C.[K+]>CN(C)C=O>[CH2:12]([O:14][C:15](=[O:24])[CH:16]([C:17]1[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][CH:18]=1)[CH2:2][CH2:3][O:4][Si:5]([C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:7])[CH3:6])[CH3:13]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilane2회HCID 7020609Ethyl 2-(4-bromophenyl)acetateHCID 23665647Potassium tert-butoxide

생성물 1

HCID 592383032-(4-Bromo-phenyl)-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid ethyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-(4-Bromo-phenyl)-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid ethyl ester (XXXI) is prepared by alkylation of the corresponding potassium enolate with XXX. The reaction is typically carried out by deprotonating (4-bromo-phenyl)-acetic acid ethyl ester with potassium tert-butoxide in dimethylformamide at room temperature for one hour, then cooling the reaction to zero degrees Celsius and slowly adding XXX, followed by stirring at room temperature for twelve hours.

후처리

  1. customat room temperature
  2. customfor one hour
  3. temperaturecooling
  4. customthe reaction to zero degrees Celsius

출처 및 근거

ORD 기록
ord-bb2fcee14b8e4bcdba253e89485a65b3
출처 데이터셋
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08202866B2

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