(E)-3-(2-(Dimethylamino)vinyl)-4-nitropyridine 1-oxide → 5-Azaindole

HRID 2201791노트

반응식

HRID 2201791 반응식
CN(C)/[CH:3]=[CH:4]/[C:5]1[CH:6]=[N+:7]([O-])[CH:8]=[CH:9][C:10]=1[N+:11]([O-])=O>CO.[Pd]>[NH:11]1[C:10]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[CH:4]=[CH:3]1

참가 물질

4

반응물 1

HCID 11344817(E)-3-(2-(Dimethylamino)vinyl)-4-nitropyridine 1-oxide

생성물 1

HCID 92205-Azaindole수율 44%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a suspension of (E)-N,N-dimethyl-2-(4-nitro-1-oxidopyridin-3-yl)ethenamine (400 mg, Step c) in methanol was added palladium on carbon (50 mg, 10% wet) and the reaction mixture was stirred under hydrogen atmosphere for 2 hours. The reaction mixture was filtered through celite and the filtrate was concentrated to get 1H-pyrrolo[3,2-c]pyridine (98 mg, 44%) as off-white solid.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-64ba046631ea44ccaad1e76825a03ab7
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09364466B2

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