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Water → 2-(4-Bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionic acid

HRID 220180
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HRID 220180 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:11][CH:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)C#N)=[CH:4][CH:3]=1.OS(O)(=O)=O.O.[C:25]([O-:28])([O-])=[O:26].[Na+].[Na+]>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]2)[C:25]([OH:28])=[O:26])=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 592383062-(4-Bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionitrile

생성물 1

HCID 592383282-(4-Bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionic acid

시약·촉매·용매 1

HCID 887Methanol용매
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실험 절차

The oily residue of 2-(4-bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionitrile was hydrolyzed by refluxing for 2 h with 4 mL of concentrated H2SO4 and water (38:28). The mixture was neutralized with Na2CO3, then MeOH (20 mL) was added. The solid was filtered and washed with MeOH (3×10 mL). The combined methanol solution was evaporated to give an oil. MS: calc'd 326 (MH+), exp 326 (MH+).

후처리

  1. filtrationThe solid was filtered
  2. washwashed with MeOH (3×10 mL)
  3. customThe combined methanol solution was evaporated
  4. customto give an oil

출처 및 근거

ORD 기록
ord-6b9b418d41204654b2aa2995156f50aa
출처 데이터셋
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08202866B2

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