Iodine → HCID 178505763, 화합물
반응식
[Zn:1].II.[Br:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.C[Si](Cl)(C)C>O1CCCC1>[Br-:4].[F:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][Zn+:1])=[CH:7][CH:8]=1참가 물질
6
실험 절차
To a stirred mixture of Zn metal (18.5 g, 289.06 mmol, 1.09 equiv), I2 (500 mg, 1.97 mmol, 0.01 equiv) and 1-(bromomethyl)-4-fluorobenzene (5 g, 0.10 equiv) in anhydrous tetrahydrofuran (50 mL) maintained under nitrogen at room temperature was added dropwise a solution of 1-(bromomethyl)-4-fluorobenzene (45 g, 211.6 mmol, 0.90 equiv) in tetrahydrofuran (200 mL). TMSCl (500 mg, 4.60 mmol, 0.02 equiv) was then added dropwise to the reaction. The resulting mixture was refluxed for 10 h. The solution was cooled to 0° C. and used in the next step immediately.
후처리
- temperatureThe resulting mixture was refluxed for 10 h
- temperatureThe solution was cooled to 0° C.
출처 및 근거
- ORD 기록
- ord-82d8d67e34174504a05b01a8d455fba3
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09365527B2
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