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Potassium Iodide → methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate

HRID 2202179
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HRID 2202179 반응식
C(=O)([O-])[O-].[Cs+].[Cs+].Cl[CH2:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[C:11]([CH3:19])[CH:10]=1.[I-].[K+].[OH:22][C:23]1[CH:28]=[CH:27][C:26]([S:29]([NH:32][CH2:33][C@H:34]([N:39]2[CH2:44][CH2:43][N:42]([S:45]([CH3:48])(=[O:47])=[O:46])[CH2:41][CH2:40]2)[C:35]([O:37][CH3:38])=[O:36])(=[O:31])=[O:30])=[CH:25][CH:24]=1>CC(C)=O>[CH3:48][S:45]([N:42]1[CH2:41][CH2:40][N:39]([C@@H:34]([CH2:33][NH:32][S:29]([C:26]2[CH:25]=[CH:24][C:23]([O:22][CH2:8][C:9]3[C:18]4[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=4)[N:12]=[C:11]([CH3:19])[CH:10]=3)=[CH:28][CH:27]=2)(=[O:31])=[O:30])[C:35]([O:37][CH3:38])=[O:36])[CH2:44][CH2:43]1)(=[O:46])=[O:47]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 10796Cesium carbonateHCID 115357194-(Chloromethyl)-2-methylquinolineHCID 86675015methyl (S)-3-(4-hydroxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoate

생성물 1

HCID 86675016methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate수율 32%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

280 mg (0.85 mmol) of cesium carbonate followed by 160 mg (0.85 mmol) of 4-chloromethyl-2-methylquinoline and by 15 mg of potassium iodide are added to a solution of 300 mg (0.71 mmol) of methyl (S)-3-(4-hydroxybenzenesulfonylamino)-2-(4-methanesulfonylpiperazin-1-yl)propanoate in 10 ml of acetone. The reaction medium is stirred at ambient temperature for 18 h, filtered and concentrated under vacuum. The crude product is purified by chromatography on silica gel, elution being carried out with a 40/60 heptane/ethyl acetate mixture. 130 mg (32%) of methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate are obtained in the form of a white solid.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated under vacuum
  3. customThe crude product is purified by chromatography on silica gel, elution

출처 및 근거

ORD 기록
ord-5be837c293d44bb5a9bf2d4f8d05497e
출처 데이터셋
uspto-grants-2016_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09365529B2

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