Methylamine → 6-Chloro-N-methyl-1,3-benzothiazol-2-amine

HRID 2202371노트

반응식

HRID 2202371 반응식
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:12][NH2:13]>C1COCC1.O>[Cl:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:13][CH3:12])[S:3][C:4]=2[CH:10]=1

참가 물질

5

반응물 2

HCID 6329MethylamineHCID 771762,6-Dichlorobenzothiazole

생성물 1

HCID 107743586-Chloro-N-methyl-1,3-benzothiazol-2-amine

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2,6-dichlorobenzo[d]thiazole (2 g, 10 mmol) in 10 mL THF was added 25% MeNH2 in water (3 mL) dropwise. After the addition complete, the reaction mixture was stirred at room temperature overnight. Filter off the product and washed with methanol. Drying in vacuo to yield 1.5 g of the desired compound. LC-MS: m/z 204.2 (M+H)+

후처리

  1. filtrationFilter off the product
  2. washwashed with methanol
  3. customDrying in vacuo

출처 및 근거

ORD 기록
ord-fec4847eb50948bfa3139a0e452d3549
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365545B2

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