Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → HCID 178483309, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | HCID 178488952 | HCID 178488952 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178483309 | HCID 178483309 | 37.7% |
반응 단계
A solution of 1.5 g of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-carbamic acid tert.-butyl ester in 10 mL DCM was treated with 0.39 mL of TFA and stirred overnight at rt. The reaction mixture was concentrated in vacuo, redissolved in DCM and treated with diluted NaOH. After separation of the 2 phases the water phase was lyophilized to yield 380 mg of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-amine as beige solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202885B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-9d1d1ccde96d430e95a9e09857093f57 |
| 출처 메모 | uspto-grants-2012_06 |