Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzil → 3-(4,5-diphenyl-1H-imidazol-2-yl)propionic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzil | HCID 8651 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | Methyl 4,4-dimethoxybutanoate | HCID 350846 | — |
| 반응물 | Ammonium Acetate | HCID 517165 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-(4,5-diphenyl-1H-imidazol-2-yl)propionic acid methyl ester | HCID 68413807 | — |
반응 단계
A solution of 1 g of benzil, 1.01 g of methyl 4,4-dimethoxybutyrate and 2.87 g of ammonium acetate in 23 mL of acetic acid was refluxed for 5 h. The mixture was poured into water, basified with a 25% aq. ammonium hydroxide solution and extracted with DCM. The organic phase was dried over anh. Na2SO4 and concentrated in vacuo. The resulting crude material was purified by CC using heptane/EtOAc from 85/15 to 0/100 as eluant to yield 633 mg of 3-(4,5-diphenyl-1H-imidazol-2-yl)-propionic acid methyl ester as a yellowish solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202885B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-892bcec21f6c40609c2057332dd0077b |
| 출처 메모 | uspto-grants-2012_06 |