Diisobutylaluminumhydride → 1-(Trifluoromethyl)cyclopropanecarboxaldehyde

HRID 2202672노트

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HRID 2202672 반응식
CON(C)[C:4]([C:6]1([C:9]([F:12])([F:11])[F:10])[CH2:8][CH2:7]1)=[O:5].[H-].C([Al+]CC(C)C)C(C)C>C(Cl)Cl>[F:10][C:9]([F:12])([F:11])[C:6]1([CH:4]=[O:5])[CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 21225700DiisobutylaluminumhydrideHCID 57785368N-methoxy-N-methyl-1-(trifluoromethyl)cyclopropane-1-carboxamide

생성물 1

HCID 574451861-(Trifluoromethyl)cyclopropanecarboxaldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

To a stirred solution of compound A103-1 (164 mg, 0.832 mmol) in DCM (2 mL) was added diisobutylaluminum hydride (1 M in hexane, 1.0 mL, 1.0 mmol) at −78° C. under nitrogen atmosphere. After 0.5 h, the mixture was allowed to warm to 0° C. and stirred for 0.5 h. The reaction mixture was quenched with sat. KHSO4 aq. (10 mL) and extracted with DCM (2×4 mL). The combined organic layers were directly used in the next step without further purification.

후처리

  1. customThe reaction mixture was quenched with sat. KHSO4 aq. (10 mL)
  2. extractionextracted with DCM (2×4 mL)
  3. customThe combined organic layers were directly used in the next step without further purification

출처 및 근거

ORD 기록
ord-4ab3b65041f245cb860bc5961bff4bed
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365522B2

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