FURO[2,3-B]PYRIDINE-5-METHANOL → furo[2,3-b]pyridine-5-carbaldehyde

HRID 220268노트

반응식

HRID 220268 반응식
[O:1]1[C:5]2=[N:6][CH:7]=[C:8]([CH2:10][OH:11])[CH:9]=[C:4]2[CH:3]=[CH:2]1>C(Cl)Cl>[O:1]1[C:5]2=[N:6][CH:7]=[C:8]([CH:10]=[O:11])[CH:9]=[C:4]2[CH:3]=[CH:2]1

참가 물질

3

반응물 1

HCID 10057661FURO[2,3-B]PYRIDINE-5-METHANOL

생성물 1

HCID 10749327furo[2,3-b]pyridine-5-carbaldehyde수율 82%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 0.47 g of furo[2,3-b]pyridin-5-yl-methanol in 2 ml of DCM was added 10 ml of a Dess-Martins-Periodinane solution (15% in DCM). The reaction mixture was stirred overnight and then quenched with sat.-NaHCO3 and extracted with DCM. The organic phase was washed with brine, dried over MgSO4 and concentrated in vacuo. The resulting crude material was purified by CC using heptane/EtOAc 30/70 as eluant to yield 0.38 g of furo[2,3-b]pyridine-5-carbaldehyde as white solid.

후처리

  1. customquenched with sat.-NaHCO3
  2. extractionextracted with DCM
  3. washThe organic phase was washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo
  6. customThe resulting crude material was purified by CC

출처 및 근거

ORD 기록
ord-72e69c0e05bd49c99f6f65874f1003a6
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202885B2

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