[3-(2-Amino-3-nitro-phenylcarbamoyl)-propyl]methyl-carbamic acid tert-butyl ester → methyl-[3-(4-nitro-1H-benzoimidazol-2-yl)-propyl]-carbamic acid tert-butyl ester

HRID 220281

반응식

HRID 220281 반응식
[C:1]([O:5][C:6](=[O:25])[N:7]([CH2:9][CH2:10][CH2:11][C:12](=O)[NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[C:15]=1[NH2:23])[CH3:8])([CH3:4])([CH3:3])[CH3:2]>C(O)(=O)C>[C:1]([O:5][C:6](=[O:25])[N:7]([CH3:8])[CH2:9][CH2:10][CH2:11][C:12]1[NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[C:15]=2[N:23]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 1

HCID 68412474[3-(2-Amino-3-nitro-phenylcarbamoyl)-propyl]methyl-carbamic acid tert-butyl ester

생성물 1

HCID 68412537methyl-[3-(4-nitro-1H-benzoimidazol-2-yl)-propyl]-carbamic acid tert-butyl ester수율 91%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 4.4 g of [3-(2-amino-3-nitro-phenylcarbamoyl)-propyl]methyl-carbamic acid tert-butyl ester in 36 mL of acetic acid was heated at 90° C. for 5 h and concentrated in vacuo. The residue was taken up in DCM, washed with sat. NaHCO3 solution, dried over anh. Na2SO4 and concentrated in vacuo to yield 3.8 g of methyl-[3-(4-nitro-1H-benzoimidazol-2-yl)-propyl]-carbamic acid tert-butyl ester as dark yellow oil.

후처리

  1. concentrationconcentrated in vacuo
  2. washwashed with sat. NaHCO3 solution
  3. dry with materialdried over anh. Na2SO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-4aded8f57dda4ab0a40aa39f5dd8194c
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202885B2

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