3-Furancarboxamide,tetrahydro-N-methoxy-N-methyl-(9CI) → HCID 21702750, 화합물

HRID 2202882노트

반응식

HRID 2202882 반응식
CON(C)[C:4]([CH:6]1[CH2:10][CH2:9][O:8][CH2:7]1)=[O:5].[CH2:12]([Mg]Br)[CH3:13]>C1COCC1>[O:8]1[CH2:9][CH2:10][CH:6]([C:4](=[O:5])[CH2:12][CH3:13])[CH2:7]1

참가 물질

4

반응물 2

HCID 450845223-Furancarboxamide,tetrahydro-N-methoxy-N-methyl-(9CI)HCID 178418443HCID 178418443, 화합물

생성물 1

HCID 21702750HCID 21702750, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of N-methoxy-N-methyltetrahydrofuran-3-carboxamide (4.1 g) in THF (40 ml) was added ethylmagnesium bromide (3 M in ether, 13.0 ml) at 0° C. The reaction mixture was then slowly warmed to room temperature and stirred for 4 h. The reaction mixture was quenched with saturated 1 M HCl (10 ml), and extracted with EtOAc. The extract was washed with brine, dried over Na2SO4 and concentrated in vacuo. The mixture was purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (3.0 g) as a pale yellow liquid.

후처리

  1. customThe reaction mixture was quenched with saturated 1 M HCl (10 ml)
  2. extractionextracted with EtOAc
  3. washThe extract was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo
  6. customThe mixture was purified by silica gel column chromatography (hexane/EtOAc)

출처 및 근거

ORD 기록
ord-fe1e8657f0f845d4b215a5629b6c4c54
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365540B2

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