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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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(5-Bromofuran-2-yl)methanol → 4-((5-Bromo-2-furyl)methoxy)-1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one

HRID 2203086
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HRID 2203086 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:15]=[C:14]([CH:16]4[CH2:18][CH2:17]4)[N:13]([CH3:19])[C:12]=3[CH:20]=2)[C:4](=[O:21])[CH:3]=1.[Br:22][C:23]1[O:27][C:26]([CH2:28][OH:29])=[CH:25][CH:24]=1.CC(C)([O-])C.[K+]>C1(C)C=CC=CC=1>[Br:22][C:23]1[O:27][C:26]([CH2:28][O:29][C:2]2[CH:7]=[CH:6][N:5]([C:8]3[CH:9]=[CH:10][C:11]4[N:15]=[C:14]([CH:16]5[CH2:18][CH2:17]5)[N:13]([CH3:19])[C:12]=4[CH:20]=3)[C:4](=[O:21])[CH:3]=2)=[CH:25][CH:24]=1
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참가 물질

5

반응물 3

HCID 14595701(5-Bromofuran-2-yl)methanolHCID 23665647Potassium tert-butoxideHCID 896909614-Chloro-1-(2-cyclopropyl-1-methyl-1h-benzimidazol-6-yl)-2(1h)-pyridinone

생성물 1

HCID 1213862564-((5-Bromo-2-furyl)methoxy)-1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one수율 71.7%

시약·촉매·용매 1

HCID 1140Toluene
용매

실험 절차

To a solution of 4-chloro-1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one (150 mg) and (5-bromo-2-furyl)methanol (177 mg) in toluene (2.0 ml) was added potassium tert-butoxide (112 mg) at 100° C., and the mixture was stirred for 30 min. The mixture was quenched with water (2 ml), and the precipitate was collected. The resulting solid was recrystallized from EtOH—H2O to give the title compound (158 mg) as an off-white solid.

후처리

  1. customThe mixture was quenched with water (2 ml)
  2. customthe precipitate was collected
  3. customThe resulting solid was recrystallized from EtOH—H2O

출처 및 근거

ORD 기록
ord-4cf1213d79e74e8db1fb311ed0041338
출처 데이터셋
uspto-grants-2016_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09365540B2

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