Sodium Methoxide → HCID 89691264, 화합물

HRID 2203091노트

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HRID 2203091 반응식
Cl.[CH:2]1([C:5]2[N:9]([CH3:10])[C:8]3[CH:11]=[C:12]([N:15]4[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23](=[NH:25])[NH2:24])=[CH:17][C:16]4=[O:26])[CH:13]=[CH:14][C:7]=3[N:6]=2)[CH2:4][CH2:3]1.F[P-](F)(F)(F)(F)F.[Cl:34][C:35](=[CH:40]N(C)C)[CH:36]=[N+](C)C.C[O-].[Na+]>CO>[Cl:34][C:35]1[CH:36]=[N:25][C:23]([CH2:22][O:21][C:18]2[CH:19]=[CH:20][N:15]([C:12]3[CH:13]=[CH:14][C:7]4[N:6]=[C:5]([CH:2]5[CH2:4][CH2:3]5)[N:9]([CH3:10])[C:8]=4[CH:11]=3)[C:16](=[O:26])[CH:17]=2)=[N:24][CH:40]=1

참가 물질

5

반응물 3

HCID 10942334Sodium MethoxideHCID 748906302-Chloro-3-(dimethylamino)-N,N-dimethylprop-2-en-1-iminium hexafluoridophosphate(1-)HCID 89691033HCID 89691033, 화합물

생성물 1

HCID 89691264HCID 89691264, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-((1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)ethanimidamide hydrochloride (100 mg), 2-chloro-3-(dimethylamino)-N,N-dimethylprop-2-en-1-iminium hexafluorophosphate (0.82 ml), sodium methoxide (43.3 mg) and MeOH (10 ml) was stirred at room temperature for 1 h. The mixture was concentrated, and the residue was partitioned between EtOAc and water. The extract was washed with brine, dried over MgSO4, concentrated and purified by NH silica gel column chromatography (hexane/EtOAc) to give the title compound (56 mg) as a white solid.

후처리

  1. concentrationThe mixture was concentrated
  2. customthe residue was partitioned between EtOAc and water
  3. washThe extract was washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. custompurified by NH silica gel column chromatography (hexane/EtOAc)

출처 및 근거

ORD 기록
ord-64f982d5672947d69216678564675f89
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365540B2

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