Tetrahydrofuran → Ethyl 4-(hydroxymethyl)-1,3-thiazole-2-carboxylate
반응식
[CH2:1]([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([C:11](O)=[O:12])[N:10]=1)=[O:5])[CH3:2].C1COCC1>CO>[OH:12][CH2:11][C:9]1[N:10]=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[S:7][CH:8]=1참가 물질
4
실험 절차
A mixture of 2-(ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid (2 g), boran-THF complex (1.0 M in THF, 45.2 ml) and THF (50 ml) was heated under reflux overnight. After MeOH (2.0 ml) was added to the mixture at the same temperature, the mixture was concentrated in vacuo to dryness. The residue was purified by NH silica gel column chromatography (hexane/EtOAc) to give the title compound (0.96 g) as a white solid.
후처리
- temperatureunder reflux overnight
- concentrationthe mixture was concentrated in vacuo to dryness
- customThe residue was purified by NH silica gel column chromatography (hexane/EtOAc)
출처 및 근거
- ORD 기록
- ord-e496314232ef4df18834c018eb66ffb8
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09365540B2
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