Triethylamine → 5-Bromo-2-(3-hydroxy-3-methylbutyl)isoindolin-1-one

HRID 2203218노트

반응식

HRID 2203218 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[C:4]([CH2:12]Br)[CH:3]=1.[NH2:14][CH2:15][CH2:16][C:17]([CH3:20])([OH:19])[CH3:18].CCN(CC)CC>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:10][CH:11]=1)[C:6](=[O:8])[N:14]([CH2:15][CH2:16][C:17]([OH:19])([CH3:20])[CH3:18])[CH2:12]2

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 156491734-Amino-2-methylbutan-2-olHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoate

생성물 1

HCID 231583295-Bromo-2-(3-hydroxy-3-methylbutyl)isoindolin-1-one

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
85 °C

실험 절차

To methyl 4-bromo-2-(bromomethyl)benzoate (0.220 g, 0.714 mmol) suspended in MeOH (6.0 mL) were added 4-amino-2-methylbutan-2-ol (0.077 g, 0.750 mmol) and Et3N (0.156 mL, 1.107 mmol). The mixture was heated to reflux (85° C.) for 24 hours, then cooled to RT, and concentrated in vacuo to give the title compound, which was used without further purification.

후처리

  1. temperatureThe mixture was heated
  2. temperaturecooled to RT
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b4703082cc7f4b1f9aa93a2627270c78
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365566B2

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