Oxalyl chloride → 6-Heptenoyl chloride

HRID 220337

반응식

HRID 220337 반응식
[C:1]([OH:9])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=[CH2:7].C(Cl)(=O)C([Cl:13])=O>C(Cl)Cl.CN(C=O)C>[C:1]([Cl:13])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=[CH2:7]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 707056-Heptenoic acid

생성물 1

HCID 108556156-Heptenoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 6-heptenoic acid (251 μL, 1.85 mmol) in CH2Cl2 (5 mL) at rt was added oxalyl chloride (476 μL, 5.55 mmol) and DMF (1 drop). After stirring for 1 hr, the reaction mixture was concentrated under reduced pressure and put under high vacuum for 15 min. The residual yellow oil was dissolved in CH2Cl2 (3 mL) and used as a stock solution (0.62M) for the subsequent acylation reactions.

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. waitput under high vacuum for 15 min
  3. dissolutionThe residual yellow oil was dissolved in CH2Cl2 (3 mL)

출처 및 근거

ORD 기록
ord-b8594f1c59c849589b496db5fb3485d8
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202911B2

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