Methanol → 2-ethyl-1-(2-methylpropyl)-7-(2-morpholin-4-yl-2-oxoethoxy)-1H-imidazo[4,5-c]quinoline

HRID 2203518노트

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HRID 2203518 반응식
[CH2:1]([C:3]1[N:4]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:5]2[C:14]3[CH:13]=[CH:12][C:11]([OH:15])=[CH:10][C:9]=3[N:8]=[CH:7][C:6]=2[N:16]=1)[CH3:2].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:28][C:29]([N:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1)=[O:30].CO>CN(C=O)C.O.C(OCC)C>[CH2:1]([C:3]1[N:4]([CH2:17][CH:18]([CH3:19])[CH3:20])[C:5]2[C:14]3[CH:13]=[CH:12][C:11]([O:15][CH2:28][C:29]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[O:30])=[CH:10][C:9]=3[N:8]=[CH:7][C:6]=2[N:16]=1)[CH3:2]

참가 물질

8

반응물 4

HCID 887MethanolHCID 10796Cesium carbonateHCID 139968762-Bromo-1-(morpholin-4-yl)ethan-1-oneHCID 1363478472-ethyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-ol

생성물 1

HCID 689692552-ethyl-1-(2-methylpropyl)-7-(2-morpholin-4-yl-2-oxoethoxy)-1H-imidazo[4,5-c]quinoline수율 94.9%

시약·촉매·용매 3

HCID 962Water용매HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매2회

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온도
85 °C

실험 절차

Under a nitrogen atmosphere, a mixture of 2-ethyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-ol (1.97 g, 7.31 mmol), solid cesium carbonate (4.77 g, 14.6 mmol), and DMF (105 mL) was heated at 85° C. for 30 minutes. The heat was removed, and a solution of 4-(2-bromoacetyl)morpholine (1.83 g, 8.77 mmol) in DMF (20 mL) was added over a period of 12 minutes. The reaction was heated at 85° C. for 3.5 hours, and methanol (1 mL) was then added. The reaction mixture was filtered to remove solids, and the filtrate was concentrated under reduced pressure to provide an orange oil. The oil was triturated with ethyl acetate and water to provide a fluffy, white solid that was isolated by filtration. The filtrate was concentrated under reduced pressure to provide a solid that was stirred with diethyl ether and water and isolated by filtration. The two solids were combined and dried in a vacuum oven at 60° C. to provide 2.75 g of 2-ethyl-1-(2-methylpropyl)-7-(2-morpholin-4-yl-2-oxoethoxy)-1H-imidazo[4,5-c]quinoline as a yellow semi-solid.

후처리

  1. customThe heat was removed
  2. temperatureThe reaction was heated at 85° C. for 3.5 hours
  3. filtrationThe reaction mixture was filtered
  4. customto remove solids
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customto provide an orange oil
  7. customThe oil was triturated with ethyl acetate and water
  8. customto provide a fluffy, white solid
  9. customthat was isolated by filtration
  10. concentrationThe filtrate was concentrated under reduced pressure
  11. customto provide a solid
  12. customisolated by filtration
  13. customdried in a vacuum oven at 60° C.

출처 및 근거

ORD 기록
ord-46a55c214fc34a0998c53837c90530ea
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365567B2

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