Bromine → 1-Bromo-1-(methylsulfonyl)-2-propanone

HRID 220370

반응식

HRID 220370 반응식
[CH3:1][S:2]([CH2:5][C:6](=[O:8])[CH3:7])(=[O:4])=[O:3].[Br:9]Br>CC(O)=O.ClCCl>[Br:9][CH:5]([S:2]([CH3:1])(=[O:4])=[O:3])[C:6](=[O:8])[CH3:7]

참가 물질

5

반응물 2

HCID 24408BromineHCID 786951-(Methylsulphonyl)acetone

생성물 1

HCID 581805331-Bromo-1-(methylsulfonyl)-2-propanone수율 42.1%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 6344Dichloromethane용매

실험 절차

To a solution of methanesulphonylacetone (0.5 g, 3.67 mmol) in AcOH (7.34 mL) and dichloromethane (11.02 mL) in a round bottom flask was added bromine (0.189 mL, 3.67 mmol) dropwise. The reaction mixture was stirred at rt 90 min. Solvent was removed in vacuo. The residue was taken up in ether and washed with saturated aqueous sodium bicarbonate (2×). The organics were concentrated in vacuo. 1-Bromo-1-(methylsulfonyl)propan-2-one (0.332 g, 42% yield) was isolated as an oil.

후처리

  1. customSolvent was removed in vacuo
  2. washwashed with saturated aqueous sodium bicarbonate (2×)
  3. concentrationThe organics were concentrated in vacuo

출처 및 근거

ORD 기록
ord-d904e2e21c024f3489eba3c9a23001ad
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202881B2

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