Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Hydrazinopyridine → 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Hydrazinopyridine | HCID 78645 | — |
| 반응물 | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9856256 | 97.2% |
반응 단계
Dissolve 2-acetyl-3-oxobutyric acid ethyl ester (20.74 g, 0.120 mol) and 2-pyridylhydrazine (14.5 mL, 0.133 mol) in acetic acid (160 mL) and stir the mixture for 18 hr. Concentrate, dilute with DCM, wash with saturated sodium bicarbonate, dry (sodium sulfate), filter and concentrate to give 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester as an oil (28.6 g, 97%). MS (APCI): m/z=246 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202873B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-8084db007efd497d9560deff49f3af73 |
| 출처 메모 | uspto-grants-2012_06 |