Potassium Carbonate → Ethyl 2-(2-methylimidazo[2,1-b]thiazol-6-yl)acetate
반응식
Br.[CH3:2][C:3]1[S:7][C:6]2=[N:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][N:5]2[CH:4]=1.C(=O)([O-])[O-].[K+].[K+]>O>[CH3:2][C:3]1[S:7][C:6]2=[N:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][N:5]2[CH:4]=1참가 물질
4
실험 절차
Ethyl (2-methylimidazo[2,1-b][1,3]thiazol-6-yl)acetate hydrobromide (226 g, 0.74 mol) was dissolved in water (350 mL) and the solution was adjusted to pH 7 by addition of potassium carbonate (51.0 g, 0.37 mol). The aqueous solution was extracted with methylene chloride (300 mL) and the organic phase was washed with brine (150 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give ethyl (2-methylimidazo[2,1-b][1,3]thiazol-6-yl)acetate as a brown oil (151.3 g).
후처리
- extractionThe aqueous solution was extracted with methylene chloride (300 mL)
- washthe organic phase was washed with brine (150 mL)
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-724238e37e43407da29e572879ecbebc
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09370516B2
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