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Sodium Carbonate → HCID 90388062, 화합물

HRID 2205196
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HRID 2205196 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]([S:14]([C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)(=[O:16])=[O:15])[C:7](B1OC(C)(C)C(C)(C)O1)=[CH:6]2.[Cl:33][C:34]1[CH:35]=[CH:36][C:37]2[N:38]([C:40](I)=[CH:41][N:42]=2)[N:39]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(#N)C.[Pd]>[Cl:33][C:34]1[CH:35]=[CH:36][C:37]2[N:38]([C:40]([C:7]3[N:8]([S:14]([C:17]4[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=4)(=[O:16])=[O:15])[C:9]4[C:5]([CH:6]=3)=[CH:4][C:3]([O:2][CH3:1])=[C:11]([O:12][CH3:13])[CH:10]=4)=[CH:41][N:42]=2)[N:39]=1
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참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 532498976-Chloro-3-iodoimidazo[1,2-b]pyridazineHCID 90388490HCID 90388490, 화합물

생성물 1

HCID 90388062HCID 90388062, 화합물수율 63.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6342Acetonitrile
용매

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온도
150 °C

실험 절차

To a solution of 5,6-dimethoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole (120 mg, 0.262 mmol, 1.0 equiv) in acetonitrile (3.41 mL) was added 6-chloro-3-iodoimidazo[1,2-b]pyridazine (95 mg, 0.341 mmol, 1.3 equiv), palladium catalyst (25 mg, 0.0341 mmol, 0.1 equiv) and sodium carbonate (3.41 mL, 1.0 M, 10.0 equiv). The solution was stirred at 150° C. in the microwave for 10 minutes. Purification using column chromatography gave 80 mg of the yellow solid, 63%.

후처리

  1. customPurification

출처 및 근거

ORD 기록
ord-8045c38c51ff49b9ae9020f15fbdec83
출처 데이터셋
uspto-grants-2016_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09370515B2

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