Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 220546생성일: 2026년 10월 27일
Hydrochloric Acid → 3'-Chloro-4-(1,5-dimethyl-1h-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2h-[1,2']bipyrazinyl hydrochloride salt
https://huagongshe.com/reaction/220546
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | 3'-chloro-4-(1,5-dimethyl-1H-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl | HCID 59438216 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 3'-Chloro-4-(1,5-dimethyl-1h-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2h-[1,2']bipyrazinyl hydrochloride salt | HCID 86641661 | 87% |
반응 단계
Charge a 2 L 3-neck round bottom flask with methanol (95 mL) and chill to 2° C. and slowly add acetyl chloride (7.62 mL, 0.107 mol) dropwise under nitrogen. In a separate 1 L 3-neck flask, dissolve 3′-chloro-4-(1,5-dimethyl-1H-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (36.5 g, 0.107 mol) in toluene (365 mL). Add this solution to the methanolic HCl solution in one portion. Stir vigorously for 1 hr. and concentrate to one half volume and filter to give 3′-chloro-4-(1,5-dimethyl-1H-pyrazol-4-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl hydrochloride as a white solid (25.5 g, 87%). MS (ES): m/z=307.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08202873B2 |
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| 출처 데이터셋 | uspto-grants-2012_06 |
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| ORD ID | ord-9413431bc6a8486aa42bb4b038323059 |
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| 출처 메모 | uspto-grants-2012_06 |
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