Potassium Carbonate → 1-(difluoromethyl)-4-ethynyl-1H-pyrazole
반응식
[F:1][CH:2]([F:14])[N:3]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[N:4]1.C(=O)([O-])[O-].[K+].[K+]>CO>[F:1][CH:2]([F:14])[N:3]1[CH:7]=[C:6]([C:8]#[CH:9])[CH:5]=[N:4]1참가 물질
4
실험 절차
1-(Difluoromethyl)-4-((trimethylsilyl)ethynyl)-1H-pyrazole (Preparation 151, 413 mg, 1.9 mmole) was stirred with methanol (4 mL). Potassium carbonate (17 mg) was added and stirred at room temperature for 50 minutes. The solvent was evaporated and the residue was filtered in dichloromethane through a short pad of silica to afford the title compound (187 mg 1.31 mmole 72%). 1H-NMR (CDCl3, 500 MHz): δ 3.08 (s, 1H), 7.17 (t, J=60.5 Hz, 1H), 7.75 (s, 1H), 7.97 (s, 1H).
후처리
- customThe solvent was evaporated
- filtrationthe residue was filtered in dichloromethane through a short pad of silica
출처 및 근거
- ORD 기록
- ord-a7eac286688e4b9d9596b38ba463631b
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09371319B2
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