Hydrogen chloride-ethyl acetate → oxan-3-ylhydrazine dihydrochloride

반응식

[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][NH:8]C(OC(C)(C)C)=O)[CH2:2]1.C(OCC)(=O)C.[ClH:22]>>[ClH:22].[ClH:22].[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][NH2:8])[CH2:2]1

참가 물질

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetate

HCID 66745297tert-Butyl 2-(tetrahydro-2H-pyran-3-yl)hydrazinecarboxylate

생성물 1

HCID 75481636oxan-3-ylhydrazine dihydrochloride

실험 절차

tert-Butyl 2-(tetrahydro-2H-pyran-3-yl)hydrazinecarboxylate (3.65 g) was dissolved in 4N hydrogen chloride-ethyl acetate solution (85 mL) under ice-cooling, and the solution was stirred overnight, at room temperature. The reaction mixture was concentrated under reduced pressure to give the title compound (2.40 g).

후처리

temperaturecooling
concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록: ord-396cdd7087e6472b96c0ae7e734f85e7
출처 데이터셋: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09371320B2

반응 노트

불러오는 중…