Water → 3-iodo-4-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine

HRID 2206258노트

반응식

HRID 2206258 반응식
Cl[C:2]1[C:7]2[C:8]([I:30])=[N:9][N:10]([C:11]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH3:31][OH:32].C[O-].[Na+].O>C1COCC1>[I:30][C:8]1[C:7]2[C:2]([O:32][CH3:31])=[N:3][CH:4]=[CH:5][C:6]=2[N:10]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 23694274Sodium methanolate methanolHCID 596190194-Chloro-3-iodo-1-trityl-1h-pyrazolo[4,3-c]pyridine

생성물 1

HCID 668254573-iodo-4-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
50 °C

실험 절차

To a solution of 4-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridine (1.7 g) in THF (20 mL) was added sodium methoxide methanol solution (1.5 M, 2.7 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (1.6 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-52bd61facf5d4455aef999868947a82c
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09371320B2

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