Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formic Acid → tert-Butyl {(phenylsulphonyl)[3-(trifluoromethyl)phenyl]methyl}carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | 3-(Trifluoromethyl)benzaldehyde | HCID 67990 | — |
| 반응물 | tert-Butyl carbamate | HCID 77922 | — |
| 반응물 | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| 용매 | Methanol--water (1/1) | HCID 22242641 | — |
| 생성물 | tert-Butyl {(phenylsulphonyl)[3-(trifluoromethyl)phenyl]methyl}carbamate | HCID 59536907 | — |
반응 단계
A quantity of 4.49 g (38.29 mmol) of tert-butyl carbamate and 12.57 g (76.57 mmol) of sodium benzenesulphinate were introduced in 110 ml of methanol/water 1:2 and admixed in succession with 10 g (57.43 mmol) of 3-(trifluoromethyl)benzenecarbaldehyde and 2.87 ml (76.09 mmol) of formic acid. The mixture was stirred at RT for 30 h. The precipitated product was isolated by filtration, washed in succession with water and diethyl ether and sucked dry. Further drying in an HV gave 11.2 g (47% of theory) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202895B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-dd01c49f80e34d9485cb26a159e4f399 |
| 출처 메모 | uspto-grants-2012_06 |